Antibodies to Pf155, a Major Antigen of Plasmodium falciparum: Longitudinal Studies in Humans

Phuc Nguyen-Dinh Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333

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Klavs Berzins Department of Immunology, University of Stockholm, S-106 91 Stockholm, Sweden

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William E. Collins Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333

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Mats Wahlgren Department of Immunology, University of Stockholm, S-106 91 Stockholm, Sweden

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Rachanee Udomsangpetch Department of Immunology, University of Stockholm, S-106 91 Stockholm, Sweden

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Peter Perlmann Department of Immunology, University of Stockholm, S-106 91 Stockholm, Sweden

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Antibodies to Pf155, a major Plasmodium falciparum antigen detected in the membrane of glutaraldehyde-fixed and air-dried erythrocytes infected with P. falciparum, were studied in serum samples collected from patients treated for neurosyphilis by induced P. falciparum infection. In 3 patients with no previous documented exposure to malaria, the antibodies were detected late and reached low titers. In 5 patients with extensive previous malaria infections, the antibodies appeared rapidly and reached high titers. The immunofluorescence findings were confirmed by immunoblots. No correlation was observed between antibodies to Pf155 and antibodies detected by standard immunofluorescence with whole parasite antigen.

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