Antimalarial Activity of a Riboflavin Analog against Plasmodium vinckei in Vivo and Plasmodium falciparum in Vitro

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  • * Department of Experimental Pathology, John Curtin School of Medical Research, P.O. Box 334, Canberra ACT 2601, Australia
  • | Zoology Department, The Faculties, Australian National University, Canberra, Australia
  • | Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-Ku, Kyoto, Japan

The riboflavin analog 10-(4′-chlorophenyl)-3-methylflavin was found to have significant activity against Plasmodium vinckei vinckei when administered orally and parenterally; it was active against P. falciparum in culture. It inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. When administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against P. falciparum in vitro.