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Antimalarial Activity of a Riboflavin Analog against Plasmodium vinckei in Vivo and Plasmodium falciparum in Vitro
William B. Cowden
William B. Cowden
Department of Experimental Pathology, John Curtin School of Medical Research, P.O. Box 334, Canberra ACT 2601, Australia
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Geoffrey A. Butcher
Geoffrey A. Butcher
Zoology Department, The Faculties, Australian National University, Canberra, Australia
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Nicholas H. Hunt
Nicholas H. Hunt
Department of Experimental Pathology, John Curtin School of Medical Research, P.O. Box 334, Canberra ACT 2601, Australia
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Ian A. Clark
Ian A. Clark
Zoology Department, The Faculties, Australian National University, Canberra, Australia
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Fumio Yoneda
Fumio Yoneda
Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-Ku, Kyoto, Japan
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The riboflavin analog 10-(4′-chlorophenyl)-3-methylflavin was found to have significant activity against Plasmodium vinckei vinckei when administered orally and parenterally; it was active against P. falciparum in culture. It inhibited mouse erythrocyte glutathione reductase in a dose-dependent manner. When administered orally, 5-deazariboflavin was not active in vivo although it has been shown to have activity against P. falciparum in vitro.
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