Author:
ProCite
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Reference Manager
BibTeX
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EndNote
-
1.
Ross J.G., 1967. Studies of immunity to Fasciola hepatica: Acquired immunity in cattle, sheep, and rabbits following natural infections and vaccine procedures. J. Helminthol., 41 :393–399.
-
2.
Hall R. F., Lang B. Z., 1978. The development of an experimental vaccine against Fasciola hepatica in cattle. Proc. 82nd Ann. Mtg. U.S. Anim. Hlth. Assoc., Buffalo, New York.
-
3.
Hillyer G. V., Cervoni M., 1978. Laurell crossed immunoelectrophoresis and affinity chromatography for the purification of a parasite antigen. J. Immunol. Meth., 20 :385–390.
-
4.
Hillyer G. V., 1979. Schistosoma mansoni: Reduced worm burdens in mice immunized with isolated Fasciola hepatica antigens. Exp. Parasitol., 48 :287–295.
-
5.
Hillyer G. V., Serrano A. E., 1983. The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection in Schistosoma mansoni infection using antigens of Paragonimus westermani. Am. J. Trop. Med. Hyg., 32 :350–358.
-
6.
Hillyer G. V., Garcia Rosa M., 1983. Isolation of Fasciola hepatica/Schistosoma bovis cross-reactive antigens. Fed. Proc., 52 :3283.
-
7.
Hillyer G. V., 1984. Immunity to schistosomes using heterologous trematode antigens—A review. Vet. Parasitol., 14 :262–283.
-
8.
Hillyer G. V., 1985. Induction of immunity in mice to Fasciola hepatica with a Fasciola/Schistosoma cross-reactive defined immunity antigen. Am. J. Trop. Med. Hyg., 34 :1127–1131.
-
9.
Hillyer G. V., 1975. Use of counterelectrophoresis to detect infections of Fasciola hepatica. J. Parasitol., 61 :557–559.
-
10.
Dennis W. M., Stone W. M., Swanson L. E., 1954. A new laboratory and field diagnostic test for fluke ova in feces. J. Am. Vet. Med. Assoc., 124 :47–50.
-
11.
Schalm O. W., 1965. Veterinary Haematology, Second edition. Bailliene and Cassell Ltd., London.
-
12.
Thorpe E., Ford E. J. H., 1969. Serum enzyme and hepatic changes in sheep infected with Fasciola hepatica. J. Parasitol., 97 :619–629.
-
13.
Boray J. C., 1967. The effect of host reaction to experimental Fasciola hepatica infections in sheep and cattle. Pages 84–96 in Soulsby E. J. L., ed., The Reactions of the Host to Parasitism. Proc. 3rd Intl. Conf. World Assoc. Adv. Vet. Parasitol., Lyons. Elwert, Marburg, Germany.
-
14.
Doyle J. J., 1971. Acquired immunity to experimental infection with Fasciola hepatica in cattle. Res. Vet. Sci., 12 :527–534.
-
15.
Doyle J. J., 1973. The relationship between the duration of a primary infection and the subsequent development of an acquired resistance to experimental infections with Fasciola hepatica in calves. Res. Vet. Sci., 14 :97–103.
-
16.
Van Tiggele L. J., Over H. J., 1975. Host-parasite interactions and serology in bovine fascioliasis. Pages 73–80 in Over H. J., Armour J., eds., Facts and Reflections, Workshop on fascioliasis, Lelystad.
-
17.
Kendall S. B., Sinclair I. J., Everett G., Parfitt J. W., 1978. Resistance to Fasciola hepatica in cattle. 1. Parasitological and serological observations. J. Comp. Pathol., 88 :115–122.
-
18.
Doy T. G., Hughes D. L., 1984. Fasciola hepatica: Site of resistance to reinfection in cattle. Exp. Parasitol., 57 :274–278.
-
19.
Bitakaramire P. K., 1973. Preliminary studies on the immunization of cattle against fascioliasis using gamma-irradiated metacercariae of Fasciola gigantica. Iso. Rad. Parasitol., 111 :23–32.
-
20.
Armour J., Dargie J. D., Doyle J. J., Murray M., Robinson P., Rushton B., 1974. Immunization against fascioliasis. Proc. 3rd Intl. Congr. Parasitol., Munich. p. 494.
-
21.
Nansen P., 1975. Resistance in cattle to Fasciola hepatica induced by X-ray attenuated larvae: Results from a controlled field trial. Res. Vet. Sci., 19 :278–283.
-
22.
Younis S. A., Yagi A. I., Haroun E. M., Gameel A. A., Taylor M.G., 1985. Immunization of zebu calves against Fasciola hepatica using irradiated metacercariae. J. Helminthol., 60 :123–134.
-
23.
Urquhart G. M., Mulligan W., Tennings F. W., 1954. Artificial immunity to Fasciola hepatica in rabbits. J. Infec. Dis., 94 :126–133.
-
24.
Healy G. R., 1955. Studies on immunity to Fasciola hepatica in rabbits. J. Parasitol., 41, Suppl. 1 :25.
-
25.
Burden D. J., Harness E., Hammet N. C., 1982. Fasciola hepatica: Attempts to immunize rats in mice with metabolic and somatic antigens derived from juvenile flukes. Vet. Parasitol., 9 :261–266.
-
26.
Chapman C. B., Mitchell G. F., 1982. Fasciola hepatica: Comparative studies on fascioliasis in rats and mice. Intl. J. Parasitol., 12 :81–91.
-
27.
Hughes D. L., Harness E., Doy T. G., 1981. The different stages of Fasciola hepatica capable of inducing immunity and the susceptibility of various stages to immunological attack in the sensitized rat. Res. Vet. Sci., 30 :93–98.
-
28.
Oldham G., Hughes D. L., 1982. Fasciola hepatica: Immunization of rats by intraperitoneal injection of adult fluke antigen in Freunds' adjuvant. Exp. Parasitol., 54 :7–11.
-
29.
Lang B. Z., Hall R. F., 1977. Host-parasite relationship of Fasciola hepatica in the white mouse. VIII. Successful vaccination with culture incubate antigens and antigens from sonic disruption of immature worms. J. Parasitol., 73 :1046–1049.
-
30.
Farrell C. J., Shen D. T., Wescott R. B., Lang B. Z., 1981. An enzyme-linked immunosorbent assay for diagnosis of Fasciola hepatica infection in cattle. Am. J. Vet. Res., 42 :237–240.
-
31.
Hanna R. E. B., 1980. Fasciola hepatica: An immunofluorescent study of the antigenic changes in the tegument during development in the rat and the sheep. Exp. Parasitol., 50 :155–170.
-
32.
Hanna R. E. B., Hillyer G. V., 1984. Fasciola hepatica and Schistosoma mansoni: Immunofluorescent antigen localization and cross-reactivity. Exp. Parasitol., 57 :1–14.
-
33.
Aronstein W. S., Dalton J. P., Strand M., 1985. A Schistosoma mansoni surface glycoprotein cross-reactive with a T1 antigen of Fasciola hepatica. Am. J. Trop. Med. Hyg., 34 :889–897.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 188 | 70 | 2 |
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Acquired Resistance to Fasciola Hepatica in Cattle Using a Purified Adult Worm Antigen
George V. Hillyer
George V. Hillyer
Laboratory of Parasite Immunology, Department of Biology, University of Puerto Rico,
Río Piedras, Puerto Rico 00931
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El Tahir M. Haroun
El Tahir M. Haroun
Laboratory of Parasite Immunology, Department of Biology, University of Puerto Rico,
Río Piedras, Puerto Rico 00931
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Anabel Hernandez
Anabel Hernandez
Laboratory of Parasite Immunology, Department of Biology, University of Puerto Rico,
Río Piedras, Puerto Rico 00931
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Maricelis Soler De Galanes
Maricelis Soler De Galanes
Laboratory of Parasite Immunology, Department of Biology, University of Puerto Rico,
Río Piedras, Puerto Rico 00931
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Calves were immunized twice in 4 weeks with a Fasciola/Schistosoma cross-reactive, cross-protective defined immunity antigen (denoted FhSmIII(M) isolated from F. hepatica adult worm extracts by antibody affinity chromatography and challenged 7 weeks later with F. hepatica metacercariae. F1ukes were recovered at 16 weeks of infection at which time the immunized calves had 55% less F. hepatica than the controls. All of the immunized calves developed high antibody levels of FhSmIII(M), detectable in the ELISA, by 4 weeks after a single immunization. By 9 weeks of infection with F. hepatica the immunized calves had lower sorbitol dehydrogenase levels than the unimmunized, F. hepatica-infected control calves, indicating less liver damage in the vaccinated group. These studies demonstrate that subcellular F. hepatica macromolecules cross-reactive and cross-protective against S. mansoni also have the potential to serve as vaccines in cattle exposed to this parasitic disease.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ross J.G., 1967. Studies of immunity to Fasciola hepatica: Acquired immunity in cattle, sheep, and rabbits following natural infections and vaccine procedures. J. Helminthol., 41 :393–399.
-
2.
Hall R. F., Lang B. Z., 1978. The development of an experimental vaccine against Fasciola hepatica in cattle. Proc. 82nd Ann. Mtg. U.S. Anim. Hlth. Assoc., Buffalo, New York.
-
3.
Hillyer G. V., Cervoni M., 1978. Laurell crossed immunoelectrophoresis and affinity chromatography for the purification of a parasite antigen. J. Immunol. Meth., 20 :385–390.
-
4.
Hillyer G. V., 1979. Schistosoma mansoni: Reduced worm burdens in mice immunized with isolated Fasciola hepatica antigens. Exp. Parasitol., 48 :287–295.
-
5.
Hillyer G. V., Serrano A. E., 1983. The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection in Schistosoma mansoni infection using antigens of Paragonimus westermani. Am. J. Trop. Med. Hyg., 32 :350–358.
-
6.
Hillyer G. V., Garcia Rosa M., 1983. Isolation of Fasciola hepatica/Schistosoma bovis cross-reactive antigens. Fed. Proc., 52 :3283.
-
7.
Hillyer G. V., 1984. Immunity to schistosomes using heterologous trematode antigens—A review. Vet. Parasitol., 14 :262–283.
-
8.
Hillyer G. V., 1985. Induction of immunity in mice to Fasciola hepatica with a Fasciola/Schistosoma cross-reactive defined immunity antigen. Am. J. Trop. Med. Hyg., 34 :1127–1131.
-
9.
Hillyer G. V., 1975. Use of counterelectrophoresis to detect infections of Fasciola hepatica. J. Parasitol., 61 :557–559.
-
10.
Dennis W. M., Stone W. M., Swanson L. E., 1954. A new laboratory and field diagnostic test for fluke ova in feces. J. Am. Vet. Med. Assoc., 124 :47–50.
-
11.
Schalm O. W., 1965. Veterinary Haematology, Second edition. Bailliene and Cassell Ltd., London.
-
12.
Thorpe E., Ford E. J. H., 1969. Serum enzyme and hepatic changes in sheep infected with Fasciola hepatica. J. Parasitol., 97 :619–629.
-
13.
Boray J. C., 1967. The effect of host reaction to experimental Fasciola hepatica infections in sheep and cattle. Pages 84–96 in Soulsby E. J. L., ed., The Reactions of the Host to Parasitism. Proc. 3rd Intl. Conf. World Assoc. Adv. Vet. Parasitol., Lyons. Elwert, Marburg, Germany.
-
14.
Doyle J. J., 1971. Acquired immunity to experimental infection with Fasciola hepatica in cattle. Res. Vet. Sci., 12 :527–534.
-
15.
Doyle J. J., 1973. The relationship between the duration of a primary infection and the subsequent development of an acquired resistance to experimental infections with Fasciola hepatica in calves. Res. Vet. Sci., 14 :97–103.
-
16.
Van Tiggele L. J., Over H. J., 1975. Host-parasite interactions and serology in bovine fascioliasis. Pages 73–80 in Over H. J., Armour J., eds., Facts and Reflections, Workshop on fascioliasis, Lelystad.
-
17.
Kendall S. B., Sinclair I. J., Everett G., Parfitt J. W., 1978. Resistance to Fasciola hepatica in cattle. 1. Parasitological and serological observations. J. Comp. Pathol., 88 :115–122.
-
18.
Doy T. G., Hughes D. L., 1984. Fasciola hepatica: Site of resistance to reinfection in cattle. Exp. Parasitol., 57 :274–278.
-
19.
Bitakaramire P. K., 1973. Preliminary studies on the immunization of cattle against fascioliasis using gamma-irradiated metacercariae of Fasciola gigantica. Iso. Rad. Parasitol., 111 :23–32.
-
20.
Armour J., Dargie J. D., Doyle J. J., Murray M., Robinson P., Rushton B., 1974. Immunization against fascioliasis. Proc. 3rd Intl. Congr. Parasitol., Munich. p. 494.
-
21.
Nansen P., 1975. Resistance in cattle to Fasciola hepatica induced by X-ray attenuated larvae: Results from a controlled field trial. Res. Vet. Sci., 19 :278–283.
-
22.
Younis S. A., Yagi A. I., Haroun E. M., Gameel A. A., Taylor M.G., 1985. Immunization of zebu calves against Fasciola hepatica using irradiated metacercariae. J. Helminthol., 60 :123–134.
-
23.
Urquhart G. M., Mulligan W., Tennings F. W., 1954. Artificial immunity to Fasciola hepatica in rabbits. J. Infec. Dis., 94 :126–133.
-
24.
Healy G. R., 1955. Studies on immunity to Fasciola hepatica in rabbits. J. Parasitol., 41, Suppl. 1 :25.
-
25.
Burden D. J., Harness E., Hammet N. C., 1982. Fasciola hepatica: Attempts to immunize rats in mice with metabolic and somatic antigens derived from juvenile flukes. Vet. Parasitol., 9 :261–266.
-
26.
Chapman C. B., Mitchell G. F., 1982. Fasciola hepatica: Comparative studies on fascioliasis in rats and mice. Intl. J. Parasitol., 12 :81–91.
-
27.
Hughes D. L., Harness E., Doy T. G., 1981. The different stages of Fasciola hepatica capable of inducing immunity and the susceptibility of various stages to immunological attack in the sensitized rat. Res. Vet. Sci., 30 :93–98.
-
28.
Oldham G., Hughes D. L., 1982. Fasciola hepatica: Immunization of rats by intraperitoneal injection of adult fluke antigen in Freunds' adjuvant. Exp. Parasitol., 54 :7–11.
-
29.
Lang B. Z., Hall R. F., 1977. Host-parasite relationship of Fasciola hepatica in the white mouse. VIII. Successful vaccination with culture incubate antigens and antigens from sonic disruption of immature worms. J. Parasitol., 73 :1046–1049.
-
30.
Farrell C. J., Shen D. T., Wescott R. B., Lang B. Z., 1981. An enzyme-linked immunosorbent assay for diagnosis of Fasciola hepatica infection in cattle. Am. J. Vet. Res., 42 :237–240.
-
31.
Hanna R. E. B., 1980. Fasciola hepatica: An immunofluorescent study of the antigenic changes in the tegument during development in the rat and the sheep. Exp. Parasitol., 50 :155–170.
-
32.
Hanna R. E. B., Hillyer G. V., 1984. Fasciola hepatica and Schistosoma mansoni: Immunofluorescent antigen localization and cross-reactivity. Exp. Parasitol., 57 :1–14.
-
33.
Aronstein W. S., Dalton J. P., Strand M., 1985. A Schistosoma mansoni surface glycoprotein cross-reactive with a T1 antigen of Fasciola hepatica. Am. J. Trop. Med. Hyg., 34 :889–897.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 188 | 70 | 2 |
| Full Text Views | 2 | 0 | 0 |
| PDF Downloads | 0 | 0 | 0 |