Adaptation of the Panama II Strain of Plasmodium Falciparum to Panamanian Owl Monkeys

Richard N. Rossan Gorgas Memorial Laboratory, P.O. Box 935, APO Miami, Florida 34002-0012

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David C. Baerg Gorgas Memorial Laboratory, P.O. Box 935, APO Miami, Florida 34002-0012

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The Panama II strain of Plasmodium falciparum, acquired at the second passage level in splenectomized Colombian owl monkeys, was adapted to owl monkeys of Panamanian origin. Patent infections were induced in 22 of 27 unaltered and 20 of 21 splenectomized recipients during 19 serial passages. The infections were significantly more virulent in splenectomized than normal Panamanian owl monkeys, however recrudescences in seven normal monkeys achieved peak parasitemias 48 times greater than in the primary attack. These results describe the first reproducible infections of indigenous falciparum malaria in Panamanian owl monkeys.

  • 1.

    Young M. D. , Baerg D. C. , Rossan R. N. , 1975. Experimental hosts for human plasmodia. Exp. Parasitol., 38 :136162.

  • 2.

    Young M. D. , Baerg D. C. , Rossan R. N. , 1970. Observations on Plasmodium falciparum infections in New World monkeys. J. Parasitol., 56 (Sect. II, Part 2): 485486 (Abstract).

    • Search Google Scholar
    • Export Citation
  • 3.

    Rossan R.N. , Christensen H. A. , Harper J. S. III , 1981. Adaptation of a Nigerian strain of Plasmodium falciparum to Panamanian Aotus trivirgatus. Am. J . Trop. Med. Hyg., 30 :289290.

    • Search Google Scholar
    • Export Citation
  • 4.

    Rossan R. N. , Harper J. S. III , Davidson D. E. Jr. , Escajadillo A. , Christensen H. A. , 1985. Comparison of Plasmodium falciparum infections in Panamanian and Colombian owl monkeys. Am. J. Trap. Med. Hyg., 34 :10371047.

    • Search Google Scholar
    • Export Citation
  • 5.

    Collins W. E. , Neva F. A. , Chaves-Carballo E. , Stanfill P. S. , Richardson B. B. , 1973. Studies on human malaria in Aotus monkeys. II. Establishment of a strain from Panama. J. Parasitol., 59 :609612.

    • Search Google Scholar
    • Export Citation
  • 6.

    Hershkovitz P. , 1983. Two new species of night monkeys, genus Aotus (Cebidae, Platyrrhina): A preliminary report on Aotus taxonomy. Am. J . Primatol., 4 :209243.

    • Search Google Scholar
    • Export Citation
  • 7.

    Porter J. A. Jr. , Young M. D. , 1966. Susceptibility of Panamanian primates to Plasmodium vivax. Milit. Med., 131 :952958.

  • 8.

    Collins W. E. , Stanfill P. S. , Skinner J. C. , Harrison A. J. , Smith C. S. , 1974. Studies on human malaria in Aotus monkeys. IV. Development of Plasmodium falciparum in two subspecies of Aotus trivirgatus. J. Parasitol., 60 :355358.

    • Search Google Scholar
    • Export Citation
  • 9.

    Schmidt L. H. , 1978. Plasmodium falciparum and Plasmodium vivax infections in the owl monkey (Aotus trivirgatus). 1. The courses of untreated infections. Am. J. Trap. Med. Hyg., 27 :671702.

    • Search Google Scholar
    • Export Citation
  • 10.

    Hommel M. , David P. H. , Oligino L. D. , 1983. Surface alterations of erythrocytes in Plasnwdium falciparum malaria. J. Exp. Med., 157 :11371148.

    • Search Google Scholar
    • Export Citation
  • 11.

    Marsh K. , Howard R. J. , 1986. Antigens induced on erythrocytes by P. falciparum: Expression of diverse and conserved determinants. Science, 231 :150152.

    • Search Google Scholar
    • Export Citation
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