Plasmodium Falciparumin Kinshasa, Zaire: In Vitro Drug Susceptibility Studies

Phuc Nguyen-Dinh * Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

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Alan E. Greenberg * Malaria Branch, Division of Parasitic Diseases, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333

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Ndoko Kabote † DepartMent of Pediatrics, Marna Yerno Hospital, Kinshasa, Zaire

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Farzin Davachi † DepartMent of Pediatrics, Marna Yerno Hospital, Kinshasa, Zaire

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Bernard Goussard ‡ Institut National de Recherche Biomedicale, Kinshasa, Zaire

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Binyingo Embonga § Ministry of Public Health and Social Affairs, Kinshasa, Zaire

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DOI:
https://doi.org/10.4269/ajtmh.1987.37.217
Volume/Issue:
Volume 37: Issue 2
Page(s):
217–219
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In June 1986, Plasmodium falciparum parasites were collected from 33 children presenting at the Mama Yemo Hospital in Kinshasa (Zaire) and were successfully tested in vitro by a 48-hr reinvasion test for their susceptibility to various antimalarial drugs. In vitro resistance to chloroquine was found in 82% of the isolates, a marked increase over findings obtained by the same technique 3 years ago in Kinshasa. In vitro chloroquine resistance was not associated with a history of previous drug intake. The inhibitory endpoints for quinine varied from 0.03 to 1 µM, and correlated with the chloroquine endpoints in the corresponding isolates (r = 0.64). Pyrimethamine resistance in vitro was demonstrated in 52% of the isolates tested.

Copyright:
© The American Society of Tropical Medicine and Hygiene 1987
Accepted:
23 Apr 1987
|
Published Online:
01 Sep 1987
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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