Human and Primate Malarial Sera Inhibit Fc Receptor-Mediated Phagocytosis

Hannah Lustig ShearDepartment of Medical and Molecular Parasitology, New York University Medical Center, New York, New York 10016

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James BrownMedical Research Council Laboratories, The Gambia, West Africa

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Jurg GysinInstitut Pasteur, B.P. 304, Cayenne, 97300, French, Guyana

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James B. JensenDepartment of Microbiology and Public Health, Michigan State University, East Lansing, Michigan 48824

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Savanat TharavanijDepartment of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok 4, Thailand

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Sera obtained from humans in P. falciparum-endemic regions and from P. vivax-infected Saimiri sciureus were assayed for their ability to inhibit Fc receptor-mediated phagocytosis. Some sera of humans exposed to P. falciparum from The Gambia, Sudan, and Thailand inhibited ingestion via the Fc receptor by normal human monocytes. In addition, sera from infected monkeys and a high molecular weight fraction of infected monkey serum inhibited ingestion of EIgG by normal monkey spleen macrophages. Generally, inhibition was correlated with higher parasitemia and higher IFA titers.

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