Functional and Antigenic Maturation of Brugia malayi Microfilariae

Juliet A. Fuhrman Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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Sandy S. Urioste Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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Bruce Hamill Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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Andrew Spielman Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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Willy F. Piessens Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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DOI:
https://doi.org/10.4269/ajtmh.1987.36.70
Volume/Issue:
Volume 36: Issue 1
Page(s):
70–74
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Brugia malayi microfilariae of specified ages were obtained from gerbils implanted with fertile adult worms. Such microfilariae were tested for their capacity to infect mosquitoes. A strong age dependence was found for the microfilariae's capacity to: penetrate the mosquito midgut, exsheath in response to 20 mM calcium, and develop to third stage larvae in the mosquito. In addition, differences were found between 2-day-old microfilariae and controls (from larva-infected gerbils) in their reactivities with a series of monoclonal antibodies. Thus, defined immunochemical changes occur in microfilariae as they assume functional maturity.

Author Notes

Copyright:
Copyright © 1987 by The American Society of Tropical Medicine and Hygiene 1987
Accepted:
05 Aug 1986
|
Published Online:
01 Jan 1987
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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