Clinical and Laboratory Characterization of a Chloroquine-Resistant Plasmodium falciparum Strain Acquired in the Central African Republic

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  • * Georgetown University Hospital, 3800 Reservoir Road, NW, Washington, DC 20007
  • | ** Malaria Laboratory, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100
  • | Malaria Branch, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia 30333

This case of chloroquine prophylaxis failure occurred in the Central African Republic, a country heretofore unaffected by chloroquine resistance. The clinical findings and chloroquine blood levels and blood smears confirmed prophylaxis failure. In vitro susceptibility testing demonstrated the parasite to be 3- to 4-fold more resistant than a susceptible reference clone.