Inhibition of Polyamine Biosynthesis by α-Difluoromethylornithine in African Trypanosomes and Pneumocystis carinii as a Basis of Chemotherapy: Biochemical and Clinical Aspects

Peter P. McCann Merrell Dow Research Institute, Cincinnati, Ohio 45215

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Cyrus J. Bacchi Haskins Laboratories and Department of Biology, Pace University, New York, New York 10038

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Allen B. Clarkson Jr. Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010

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Philippe Bey Merrell Dow Research Institute, Cincinnati, Ohio 45215

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Albert Sjoerdsma Merrell Dow Research Institute, Cincinnati, Ohio 45215

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Paul J. Schecter Merrell Dow Research Institute, Cincinnati, Ohio 45215

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Peter D. Walzer Cincinnati Veterans Administration Medical Center and Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267

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John L. R. Barlow Merrell Dow Research Institute, Cincinnati, Ohio 45215

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The symposium provided dramatic evidence of the value of the use of polyamine inhibition via α-difluoromethylornithine (DFMO, eflornithine) for advances in chemotherapy of Trypanosoma brucei gambiense sleeping sickness and Pneumocystis carinii pneumonia in acquired immune deficiency syndrome (AIDS) and also for further understanding the metabolic importance of the ubiquitous polyamines in these organisms.

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