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The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Leishmania major: Antileishmanial Activity of Methylbenzethonium Chloride

J. El-OnDepartment of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Laboratory for Electron Microscopy, Tel Aviv Medical Center, Beer Sheva, Israel

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G. MesserDepartment of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Laboratory for Electron Microscopy, Tel Aviv Medical Center, Beer Sheva, Israel

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DOI:
https://doi.org/10.4269/ajtmh.1986.35.1110
Volume/Issue:
Volume 35: Issue 6
Page(s):
1110–1116
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Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 µg ml-1. MBCl at 2 µg ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.
Copyright:
Copyright © 1986 by The American Society of Tropical Medicine and Hygiene 1986
Accepted:
19 Jun 1986
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Published Online:
Nov 1986
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