Bone Marrow Aspirate Culture Superior to Streptokinase Clot Culture and 8 ml 1:10 Blood-to-Broth Ratio Blood Culture for Diagnosis of Typhoid Fever

Stephen L. Hoffman U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Stephen L. Hoffman in
Current site
Google Scholar
PubMed
Close
,
David C. Edman U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by David C. Edman in
Current site
Google Scholar
PubMed
Close
,
Narain H. Punjabi U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Narain H. Punjabi in
Current site
Google Scholar
PubMed
Close
,
Murad Lesmana U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Murad Lesmana in
Current site
Google Scholar
PubMed
Close
,
Abdul Cholid U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Abdul Cholid in
Current site
Google Scholar
PubMed
Close
,
Sientje Sundah U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Sientje Sundah in
Current site
Google Scholar
PubMed
Close
, and
Jamas Harahap U.S. Naval Medical Research Unit No. 2 (USNAMRU-2), Jakarta Detachment, and Infectious Diseases Hospital, Jakarta, Indonesia

Search for other papers by Jamas Harahap in
Current site
Google Scholar
PubMed
Close
Restricted access

We compared the sensitivities of bone marrow aspirate culture (BMAC), 3 ml 1:4 and 8 ml 1:10 blood-to-broth ratio blood cultures (BC), 8 ml streptokinase clot culture (STKCC) and rectal swab culture (RSC) for isolating Salmonella typhi and S. paratyphi A from 61 patients with typhoid or paratyphoid fever in Jakarta, Indonesia. BMAC (92%) was significantly more sensitive than 8 ml BC (62%), 8 ml STKCC (51%), 3 ml BC (44%), RSC (56%) and the 19 ml combination of all three BC methods (71%). The combination of the three BC methods and RSC had an isolation rate of 87%. In Jakarta the diagnosis of typhoid fever cannot be confidently excluded unless a BMAC is done.

Author Notes

Save