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Transport of nutrients into animal cells is driven by transmembrane gradient of Na+ across the plasma membrane. The protozoan malaria parasite, Plasmodium falciparum, however, grows within the host human erythrocytes, in which the cytoplasmic concentration of Na+ is maintained low by the membrane Na+, K+-ATPase. Our experiments show that human erythrocytes enriched with Na+ by treatment with ouabain (an inhibitor of the ATPase) will support the growth of P. falciparum in culture.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 494 | 247 | 4 |
Full Text Views | 4 | 1 | 0 |
PDF Downloads | 3 | 1 | 0 |