| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 494 | 247 | 4 |
| Full Text Views | 4 | 1 | 0 |
| PDF Downloads | 3 | 1 | 0 |
Growth of Plasmodium Falciparum in Sodium-Enriched Human Erythrocytes
Kazuyuki Tanabe
Kazuyuki Tanabe
Search for other papers by Kazuyuki Tanabe in
Current site
Google Scholar
PubMed
Search for other papers by Kazuyuki Tanabe in
Current site
Google Scholar
PubMed
Akihisa Izumo
Akihisa Izumo
Search for other papers by Akihisa Izumo in
Current site
Google Scholar
PubMed
Search for other papers by Akihisa Izumo in
Current site
Google Scholar
PubMed
Katsuhiro Kageyama
Katsuhiro Kageyama
Department of Medical Zoology
Search for other papers by Katsuhiro Kageyama in
Current site
Google Scholar
PubMed
Search for other papers by Katsuhiro Kageyama in
Current site
Google Scholar
PubMed
Transport of nutrients into animal cells is driven by transmembrane gradient of Na+ across the plasma membrane. The protozoan malaria parasite, Plasmodium falciparum, however, grows within the host human erythrocytes, in which the cytoplasmic concentration of Na+ is maintained low by the membrane Na+, K+-ATPase. Our experiments show that human erythrocytes enriched with Na+ by treatment with ouabain (an inhibitor of the ATPase) will support the growth of P. falciparum in culture.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 494 | 247 | 4 |
| Full Text Views | 4 | 1 | 0 |
| PDF Downloads | 3 | 1 | 0 |