Mansonella Ozzardi in Haiti

IV. Evaluation of Antibody Reactivity to Heterologous Antigens

Stephen P. Katz International Collaboration in Infectious Disease Research (ICIDR) Program, Tulane University, New Orleans, Louisiana 70112

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Christian P. Raccurt Service de Microbiologie, Faculté de Médécine, Port-au-Prince, Haiti

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Robert C. Lowrie Jr. International Collaboration in Infectious Disease Research (ICIDR) Program, Tulane University, New Orleans, Louisiana 70112

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Jacques Boncy Service de Microbiologie, Faculté de Médécine, Port-au-Prince, Haiti

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Lily M. Leiva International Collaboration in Infectious Disease Research (ICIDR) Program, Tulane University, New Orleans, Louisiana 70112

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Sera from individuals in an area of Haiti endemic for Mansonella ozzardi were analyzed for reactivity to antigens of Brugia pahangi, Dirofilaria immitis, Mansonella llewellyni or Ascaris lumbricoides using either an enzyme-linked immunosorbent assay or an indirect immunofluorescent antibody test. IgM and IgG reactivity to all antigens was observed with sera from both microfilaremic and amicrofilaremic individuals when compared to reactivity of sera from individuals from nonendemic areas. Antibody reactivity to B. pahangi was greater than that to other antigens. IgG reactivity of sera from endemic patients to filarial antigens was consistently greater than that of IgM. Antibody reactivity was not correlated with age or microfilarial density.

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