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Effects of Chloroquine, Amodiaquine and Pyrimethamine-Sulfadoxine on Plasmodium Falciparum Gametocytemia
G. Thomas Strickland
G. Thomas Strickland
Clinical Epidemiology Department, International Center for Medical Research and Training, International Health Program, University of Maryland School of Medicine, Lahore, Pakistan
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Emile Fox
Emile Fox
Clinical Epidemiology Department, International Center for Medical Research and Training, International Health Program, University of Maryland School of Medicine, Lahore, Pakistan
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Mohammad Sarwar
Mohammad Sarwar
Clinical Epidemiology Department, International Center for Medical Research and Training, International Health Program, University of Maryland School of Medicine, Lahore, Pakistan
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Amir A. Khaliq
Amir A. Khaliq
Clinical Epidemiology Department, International Center for Medical Research and Training, International Health Program, University of Maryland School of Medicine, Lahore, Pakistan
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Michael Macdonald
Michael Macdonald
Clinical Epidemiology Department, International Center for Medical Research and Training, International Health Program, University of Maryland School of Medicine, Lahore, Pakistan
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The effects of chloroquine, amodiaquine and pyrimethamine-sulfadoxine (SP) (Fansidar) on the infection rate and density of Plasmodium flaciparum gametocytes were studied in 198 patients with falciparum malaria from an area in the Punjab where malaria is endemic but seasonally transmitted. One month following treatment of 100 patients, SP had reduced the gametocyte carrier rate from 37% to 6% and the mean gametocyte density from 80 to 1.4 per mm3 of blood. Chloroquine and amodiaquine were much less effective. Since SP has no gametocytocidal properties and the reduction in gametocytes coincided with clearance of asexual parasitemias, gametocytes were probably reduced subsequent to the cure of the asexual malaria infections. If used during the nontransmission season, SP might be an effective component of an integrated program for reducing malaria transmission in the Punjab and other areas where 4-aminoquinoline-resistant and SP-sensitive falciparum malaria exists.
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| Past two years | Past Year | Past 30 Days | |
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