Malaria Transmitted to Humans by Mosquitoes Infected from Cultured Plasmodium falciparum

Jeffrey D. Chulay Walter Reed Army Institute of Research, Washington, DC 20307-5100

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Imogene Schneider Walter Reed Army Institute of Research, Washington, DC 20307-5100

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Thomas M. Cosgriff U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701

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Stephen L. Hoffman

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W. Ripley Ballou Walter Reed Army Institute of Research, Washington, DC 20307-5100

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Isabella A. Quakyi Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205

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Richard Carter Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, Maryland 20205

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James H. Trosper Naval Medical Research Institute, Bethesda, Maryland 20814

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Wayne T. Hockmeyer Walter Reed Army Institute of Research, Washington, DC 20307-5100

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Malaria was transmitted to six normal human volunteers by mosquitoes infected from cultured gametocytes of Plasmodium falciparum. This method, which offers advantages over other methods of infecting volunteers, will be useful for evaluating the efficacy of human malaria vaccines.

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