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Effects of Fansidar on Chloroquine-Resistant Plasmodium falciparum in Pakistan
G. Thomas Strickland
G. Thomas Strickland
Clinical Epidemiology Department, International Center for Medical Research and Training, Lahore, Pakistan
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Amir A. Khaliq
Amir A. Khaliq
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Mohammad Sarwar
Mohammad Sarwar
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Hadi Hassan
Hadi Hassan
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Mohammad Pervez
Mohammad Pervez
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Emile Fox
Emile Fox
Clinical Epidemiology Department, International Center for Medical Research and Training, Lahore, Pakistan
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Fansidar (SP), a combination of sulfadoxine and pyrimethamine, was evaluated for its usefulness as a curative agent for treating individual malaria patients and for reducing the community reservoir of Plasmodium falciparum in 4 villages near Lahore, Pakistan, where resistance of 4-aminoquinolines has recently been reported. Following the end of the major malaria transmission season, we carried out a month-long mass treatment campaign during which SP was given to all available villagers who had parasitemias detected during a concurrent house-to-house malaria blood film survey. Of the 82 falciparum patients followed for 14 days after SP treatment, 80 (97.5%) had parasites sensitive to the investigated drug. Parasitemia clearance time after SP was remarkedly short (1.25 ± 0.53 days; mean ± SD). However, we were unable to reduce the parasite reservoir of P. falciparum and P. vivax in these villages, probably because we treated only 337, about one-third, of the parasitemic patients. We conclude that SP is an effective drug for treating individual malaria patients from areas in Pakistan where 4-aminoquinoline-resistant parasites are present, but that more research is needed for assessing its usefulness in reducing community reservoirs of malaria.
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| Past two years | Past Year | Past 30 Days | |
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