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Selection for Susceptibility and Refractoriness of Aedes Aegypti to Oral Infection with Yellow Fever Virus
G. P. Wallis
G. P. Wallis
Department of Biology
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T. H. G. Aitken
T. H. G. Aitken
Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06511
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B. J. Beaty
B. J. Beaty
Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06511
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L. Lorenz
L. Lorenz
Department of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06511
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G. D. Amato
G. D. Amato
Department of Biology
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W. J. Tabachnick
W. J. Tabachnick
Department of Biology, Loyola University, 6525 North Sheridan Road, Chicago, Illinois 60626
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Artificial selection on strains of Aedes aegypti showing susceptibility and refractoriness to oral infection with yellow fever virus (YFV) suggests that there is a significant genetic component to this trait. Using a population with an average susceptibility of 15%, inbreeding of isofemale lines followed by individual selection produced susceptible (29% infected) and refractory (11% infected) lines. The difference between lines was largely apparent before individual selection, which failed to increase/decrease susceptibility significantly. The findings suggest that very few loci with a major bearing on the trait segregated genetic variation in the original population sample, and that non-genetic factors also play a major role in determining whether or not Ae. aegypti females become infected with YFV.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 448 | 154 | 12 |
| Full Text Views | 13 | 5 | 0 |
| PDF Downloads | 16 | 9 | 0 |