Oral Infection of Aedes Aegypti with Yellow Fever Virus: Geographic Variation and Genetic Considerations

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  • * Department of Biology, Loyola University of Chicago, 6525 North Sheridan Road, Chicago, Illinois 60626
  • | ** Department of Zoology, Leicester University, University Road, Leicester LE1 7RH, England
  • | Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510
  • | Department of Entomology, 320 Morrill Hall, University of Illinois, Urbana, Illinois 61801
  • | § Department of Biology, Yale University, New Haven, Connecticut 06511
  • | Department of Microbiology and Environmental Health, Colorado State University, Fort Collins, Colorado 80523

Twenty-eight populations representing a worldwide distribution of Aedes aegypti were tested for their ability to become orally infected with yellow fever virus (YFV). Populations had been analyzed for genetic variations at 11 isozyme loci and assigned to one of 8 genetic geographic groups of Ae. aegypti. Infection rates suggest that populations showing isozyme genetic relatedness also demonstrate similarity to oral infection rates with YFV. The findings support the hypothesis that genetic variation exists for oral susceptibility to YFV in Ae. aegypti.