Electron Microscopy of Plasmodium Vivax Exoerythrocytic Schizonts Grown In Vitro in a Hepatoma Cell Line

Shigehiko UniInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

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Masamichi AikawaInstitute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106

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William E. CollinsMalaria Branch, Centers for Disease Control, Atlanta, Georgia 30333.

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Carlos C. CampbellMalaria Branch, Centers for Disease Control, Atlanta, Georgia 30333.

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Michael R. HollingdaleBiomedical Research Institute, Rockville, Maryland 20852

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Human hepatoma cells (HepG2-A16) have been shown to be useful for the growth of the exoerythrocytic stages of P. vivax. In order to determine whether the parasites grown in these cells are morphologically similar to those grown in vivo, we performed electron microscopy on the exoerythrocytic (EE) schizonts of P. vivax developed from sporozoites. This study showed for the first time that P. vivax EE schizonts within these cells closely resemble other plasmodial EE schizonts both in vivo and in vitro.

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