Author:
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 212 | 84 | 4 |
| Full Text Views | 6 | 1 | 0 |
| PDF Downloads | 3 | 1 | 0 |
Identification and Characterization of a Major Schistosoma Mansoni Glycoprotein Antigen Cross-Reactive with Fasciola Hepatica
William S. Aronstein
William S. Aronstein
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by William S. Aronstein in
Current site
Google Scholar
PubMed
Search for other papers by William S. Aronstein in
Current site
Google Scholar
PubMed
John P. Dalton
John P. Dalton
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by John P. Dalton in
Current site
Google Scholar
PubMed
Search for other papers by John P. Dalton in
Current site
Google Scholar
PubMed
Judith B. Weiss
Judith B. Weiss
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by Judith B. Weiss in
Current site
Google Scholar
PubMed
Search for other papers by Judith B. Weiss in
Current site
Google Scholar
PubMed
Mette Strand
Mette Strand
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by Mette Strand in
Current site
Google Scholar
PubMed
Search for other papers by Mette Strand in
Current site
Google Scholar
PubMed
A major surface antigen of Schistosoma mansoni has been identified and characterized as a glycoprotein of 66,000 molecular weight (Mr) and isoelectric point of 6.2–6.1 (SM66-GP) by use of a monoclonal antibody. The antigen was expressed by schistosome eggs, cercariae, larvae, and adults, and was recognized by sera of schistosome infected hosts. Direct immunofluorescence microscopy showed the antigen was distributed in a uniform pattern on the entire worm surface. Indirect immunofluorescence microscopy revealed that it was present in the parenchymal tissue of immature and mature Fasciola hepatica, in the gut of the mature fluke, and in embryonated fasciola eggs. The crossreactive F. hepatica epitope recognized was expressed on a polypeptide of Mr 220,000.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 212 | 84 | 4 |
| Full Text Views | 6 | 1 | 0 |
| PDF Downloads | 3 | 1 | 0 |