Isolation of a Hantaan-Related Virus from Brazilian Rats and Serologic Evidence of its Widespread Distribution in South America

James W. LeDuc United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011

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Gregory A. Smith United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21701-5011

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Francisco P. Pinheiro Pan American Health Organization, 525 Twenty-third Street, NW, Washington, DC 20037

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Pedro F. C. Vasconcelos Instituto Evandro Chagas, FSESP, Ministry of Health, Belem, Para, Brazil

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Elizabeth Salbe T. Rosa Instituto Evandro Chagas, FSESP, Ministry of Health, Belem, Para, Brazil

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Julio I. Maiztegui Instituto Nacional de Estudios sobre Virosis Hemorragicas, Pergamino, Argentina

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A serosurvey of domestic rats was conducted in several South American cities between September 1982 and March 1983 for evidence of hantavirus infection. Antibody-positive rats were found in Belem, São Paulo and Recife-Olinda, Brazil and in Buenos Aires, Argentina, with the highest antibody prevalence rate detected in Belem (30 positive of 54 tested, 56%). A virus isolated from tissues of a Rattus norvegicus captured in Belem, was shown to be antigenically similar to Girard Point viruses isolated from domestic rats captured in the United States and clearly distinct from prototype Hantaan virus, causative agent of Korean hemorrhagic fever in Asia. This represents the first isolation of a virus of the genus Hantavirus from South America and supports previous observations that indicate a widespread distribution of urban rat-associated hantaviruses. The abundance of domestic rats and their regionally high antibody rates suggest that risk of human hantavirus infection in some locations of South America may be significant.

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