High Continuous Antimony Therapy in Two Patients with Unresponsive Mucosal Leishmaniasis

Philip D. Marsden Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Raimunda N. R. Sampaio Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Edgar M. Carvalho Hospital Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brasil

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Joel P. T. Veiga Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Jackson L. M. Costa Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Elmer A. Llanos-Cuentas Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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DOI:
https://doi.org/10.4269/ajtmh.1985.34.710
Volume/Issue:
Volume 34: Issue 4
Page(s):
710–713
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The treatment of two patients with severe mucosal leishmaniasis due to Leishmania braziliensis braziliensis is described. Both patients had received much prior antimonial therapy and one had relapsed after a total dose of 2.5 g of Amphotericin B. Both patients responded to prolonged continuous Pentostam therapy at a daily dose of 20 mg Sbv/kg/day for 62 days in one case and for 85 days in the other. Pentavalent antimonials can be curative in such protracted courses in selected patients unresponsive to standard chemotherapy.

Author Notes

Copyright:
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene 1985
Accepted:
22 Feb 1985
|
Published Online:
Jul 1985
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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