High Continuous Antimony Therapy in Two Patients with Unresponsive Mucosal Leishmaniasis

Philip D. Marsden Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Raimunda N. R. Sampaio Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Edgar M. Carvalho Hospital Professor Edgard Santos, Universidade Federal da Bahia, Bahia, Brasil

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Joel P. T. Veiga Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Jackson L. M. Costa Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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Elmer A. Llanos-Cuentas Núcleo de Medicina Tropical e Nutrição, Universidade de Brasília, Brasil

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The treatment of two patients with severe mucosal leishmaniasis due to Leishmania braziliensis braziliensis is described. Both patients had received much prior antimonial therapy and one had relapsed after a total dose of 2.5 g of Amphotericin B. Both patients responded to prolonged continuous Pentostam therapy at a daily dose of 20 mg Sbv/kg/day for 62 days in one case and for 85 days in the other. Pentavalent antimonials can be curative in such protracted courses in selected patients unresponsive to standard chemotherapy.

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