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A Glycoprotein Antigen of Schistosoma mansoni Expressed on the Gynecophoral Canal of Mature Male Worms
William S. Aronstein
William S. Aronstein
Johns Hopkins University School of Medicine, Department of Pharmacology and Experimental Therapeutics, 725 North Wolfe Street, Baltimore, Maryland 21205
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Mette Strand
Mette Strand
Johns Hopkins University School of Medicine, Department of Pharmacology and Experimental Therapeutics, 725 North Wolfe Street, Baltimore, Maryland 21205
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A glycoprotein antigen of 80,000 apparent molecular weight expressed by S. mansoni eggs, cercariae, and male and female worms has been characterized by use of a monoclonal antibody prepared against cercarial glycoproteins. The antigen was expressed on the surface of both male and female worms. Its expression on the male surface, however, was restricted to the gynecophoral canal of male worms derived from fully patent infections. This pattern of surface expression suggests a role in schistosome sexual reproduction.
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