A Case of Natural Concurrent Human Infection with Two Dengue Viruses

D. J. GublerDengue Branch, Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, San Juan, Puerto Rico 00936

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G. KunoDengue Branch, Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, San Juan, Puerto Rico 00936

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G. E. SatherDengue Branch, Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, San Juan, Puerto Rico 00936

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S. H. WatermanDengue Branch, Division of Vector-Borne Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, U.S. Public Health Service, San Juan, Puerto Rico 00936

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The first documented case of concurrent human infection with 2 dengue viruses is reported. Dengue 1 and 4 viruses were isolated from the serum of a 16-year-old male during the 1982 outbreak in Puerto Rico. The illness was mild and does not support the hypothesis that double infection with dengue viruses leads to more severe hemorrhagic disease.

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