A Clinical Study of Laotian Refugees Infected with Clonorchis Sinensis or Opisthorchis Viverrini

Alan WoolfDepartment of Pediatrics

Search for other papers by Alan Woolf in
Current site
Google Scholar
PubMed
Close
,
James GreenDepartment of Pediatrics

Search for other papers by James Green in
Current site
Google Scholar
PubMed
Close
,
Judith A. LevineDepartment of Microbiology, Duke University Medical Center, Durham, North Carolina 27710

Search for other papers by Judith A. Levine in
Current site
Google Scholar
PubMed
Close
,
Enrique G. EstevezDepartment of Microbiology, Duke University Medical Center, Durham, North Carolina 27710

Search for other papers by Enrique G. Estevez in
Current site
Google Scholar
PubMed
Close
,
Norman WeatherlyDepartment of Parasitology and Laboratory Practice, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514

Search for other papers by Norman Weatherly in
Current site
Google Scholar
PubMed
Close
,
Eric RosenbergDepartment of Pediatrics

Search for other papers by Eric Rosenberg in
Current site
Google Scholar
PubMed
Close
, and
Thomas FrothinghamDepartment of Pediatrics

Search for other papers by Thomas Frothingham in
Current site
Google Scholar
PubMed
Close
Restricted access

Twenty-six Laotian refugees infected with Clonorchis or Opisthorchis liver flukes, and 15 uninfected controls, were assessed clinically by history, physical examination, serum 5′nucleotidase level, and serum immunoglobulin E level. Ultrasound studies of the biliary tract were also done on a subset of six infected subjects. The results showed no differences between subjects and controls with respect to clinical symptoms, physical findings, 5′nucleotidase, or biliary ultrasound. Mean serum IgE levels were four times higher in fluke-infected individuals than uninfected controls (P < 0.002). Even when those infected with other parasites in addition to Clonorchis were excluded from the analysis, serum IgE levels remained three times higher in fluke infected individuals (P = 0.06). This study provides some evidence that the fluke provokes a mild immune response in the asymptomatic human host but may not require eradication.

Author Notes

Present address: Comprehensive Child Health Program, Children's Hospital Medical Center, 300 Longwood Avenue, Boston, Massachusetts 02115.

Save