Typhoid Fever in Santiago, Chile: A Study of Household Contacts of Pediatric Patients

J. Glenn Morris Jr.Division of Geographic Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201

Search for other papers by J. Glenn Morris Jr. in
Current site
Google Scholar
PubMed
Close
,
Catterine Ferreccio

Search for other papers by Catterine Ferreccio in
Current site
Google Scholar
PubMed
Close
,
Julio GarciaInstitute of Public Health, Santiago, Chile

Search for other papers by Julio Garcia in
Current site
Google Scholar
PubMed
Close
,
Hernan LobosInstitute of Public Health, Santiago, Chile

Search for other papers by Hernan Lobos in
Current site
Google Scholar
PubMed
Close
,
Robert E. BlackDivision of Geographic Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201

Search for other papers by Robert E. Black in
Current site
Google Scholar
PubMed
Close
,
Hector RodriguezMinistry of Health, Santiago, Chile

Search for other papers by Hector Rodriguez in
Current site
Google Scholar
PubMed
Close
, and
Myron M. LevineDivision of Geographic Medicine and Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201

Search for other papers by Myron M. Levine in
Current site
Google Scholar
PubMed
Close
Restricted access

We obtained clinical, epidemiological, and laboratory data (including three stool cultures) from 155 (96%) of 161 household contacts of 24 patients < 16 years old with culture-confirmed typhoid fever; these 24 patients represented approximately 40% of such patients seen in three hospitals in Santiago during a 12-week period. A chronic typhoid carrier was identified in only one household, with concurrent or secondary cases seen in two other households. When index cases were matched with household members nearest in age, no specific risk factors for illness could be identified. There was evidence of generalized exposure to enteric pathogens within these households, with nine persons from seven different households culture-positive for non-typhoidal Salmonella, and nine, from eight different households, culture-positive for Shigella; transmission of these pathogens within households did not appear to be common since no household had more than one family member with the same serotype or species of either pathogen.

Save