Enhancement of the Autologous Mixed Lymphocyte Reaction in Patients with Chagas' Heart Disease

Aldina P. BarralLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil

Search for other papers by Aldina P. Barral in
Current site
Google Scholar
PubMed
Close
,
M. Barral-NettoLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil

Search for other papers by M. Barral-Netto in
Current site
Google Scholar
PubMed
Close
,
A. RassiLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil

Search for other papers by A. Rassi in
Current site
Google Scholar
PubMed
Close
,
J. M. RezendeLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil

Search for other papers by J. M. Rezende in
Current site
Google Scholar
PubMed
Close
, and
R. d'A. GusmaãoLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil

Search for other papers by R. d'A. Gusmaão in
Current site
Google Scholar
PubMed
Close
Restricted access

Autologous mixed lymphocyte reactions (AMLR) were studied in 18 individuals chronically infected with Trypanosoma cruzi. These individuals were further classified into three clinical groups: the asymptomatic indeterminate form (n = 5); the mega disease form (n = 5); and the cardiomyopathy form (n = 8). While patients with mega disease showed a normal proliferative response when compared with normal controls, the indeterminate group showed a lowered response in sharp contrast with the heart disease group, which presented a very high proliferative response to autologous non-T cells. These abnormal AMLR represent direct evidence for an immunoregulatory malfunction which may be involved in the inflammatory cardiac damage in chronic Chagas' disease.

Save