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Enhancement of the Autologous Mixed Lymphocyte Reaction in Patients with Chagas' Heart Disease
Aldina P. Barral
Aldina P. Barral
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil
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M. Barral-Netto
M. Barral-Netto
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil
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A. Rassi
A. Rassi
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil
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J. M. Rezende
J. M. Rezende
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil
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R. d'A. Gusmaão
R. d'A. Gusmaão
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Medicine, Federal University of Goias, Department of Tropical Medicine, Instituto Oswaldo Cruz (FIOCRUZ), Bethesda, Maryland 20205, Brazil
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Autologous mixed lymphocyte reactions (AMLR) were studied in 18 individuals chronically infected with Trypanosoma cruzi. These individuals were further classified into three clinical groups: the asymptomatic indeterminate form (n = 5); the mega disease form (n = 5); and the cardiomyopathy form (n = 8). While patients with mega disease showed a normal proliferative response when compared with normal controls, the indeterminate group showed a lowered response in sharp contrast with the heart disease group, which presented a very high proliferative response to autologous non-T cells. These abnormal AMLR represent direct evidence for an immunoregulatory malfunction which may be involved in the inflammatory cardiac damage in chronic Chagas' disease.
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