Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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Evaluation of the 4-Pyridinemethanol WR 180,409 (Enpiroline) in the Treatment of Induced Plasmodium Falciparum Infections in Healthy, Non-Immune Subjects

Thomas M. CosgriffWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Ellen F. BoudreauWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Charles L. Pamplin IIIWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Jonathan D. BermanWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Moshe J. ShmuklarskyWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Craig J. CanfieldWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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DOI:
https://doi.org/10.4269/ajtmh.1984.33.767
Volume/Issue:
Volume 33: Issue 5
Page(s):
767–771
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WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.
Copyright:
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene 1984
Accepted:
08 Mar 1984
|
Published Online:
Sep 1984
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