Evaluation of the 4-Pyridinemethanol WR 180,409 (Enpiroline) in the Treatment of Induced Plasmodium Falciparum Infections in Healthy, Non-Immune Subjects

Thomas M. CosgriffWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Ellen F. BoudreauWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Charles L. Pamplin IIIWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Jonathan D. BermanWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Moshe J. ShmuklarskyWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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Craig J. CanfieldWalter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20307

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WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.

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