A Monoclonal Antibody to Surface Antigens on Microfilariae of Brugia malayi Reduces Microfilaremia in Infected Jirds

M. Canlas Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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A. Wadee Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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L. Lamontagne Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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W. F. Piessens Department of Tropical Public Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115

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DOI:
https://doi.org/10.4269/ajtmh.1984.33.420
Volume/Issue:
Volume 33: Issue 3
Page(s):
420–424
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A monoclonal antibody to surface antigens of Brugia malayi microfilariae promotes the adherence of peripheral blood cells to microfilariae in vitro and reduces microfilaremia in vivo. The antibody reacts with epitopes present on two stage-specific antigens with estimated molecular weights of 70,000 and 75,000 daltons.

Author Notes

Copyright:
Copyright © 1984 by The American Society of Tropical Medicine and Hygiene 1984
Accepted:
12 Dec 1983
|
Published Online:
May 1984
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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