Safety and Toxicity of Oxamniquine in the Treatment of Schistosoma Mansoni Infections, with Particular Reference to Electroencephalographic Abnormalities

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  • Tropical Disease Unit, Department of Medicine, Toronto General Hospital, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada
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Thirty-seven patients infected with Schistosoma mansoni were treated with oxamniquine. All were cured. The only significant adverse reaction was the development of abnormal electroencephalographic (EEG) findings in 6 (17.6%) of 34 patients whose pretreatment EEG was normal. Management of patients, with particular reference to the EEG abnormalities, is discussed.