Safety and Toxicity of Oxamniquine in the Treatment of Schistosoma Mansoni Infections, with Particular Reference to Electroencephalographic Abnormalities

Sigmund KrajdenTropical Disease Unit, Department of Medicine, Toronto General Hospital, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

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Jay S. KeystoneTropical Disease Unit, Department of Medicine, Toronto General Hospital, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

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Cathie GlennTropical Disease Unit, Department of Medicine, Toronto General Hospital, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada

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Thirty-seven patients infected with Schistosoma mansoni were treated with oxamniquine. All were cured. The only significant adverse reaction was the development of abnormal electroencephalographic (EEG) findings in 6 (17.6%) of 34 patients whose pretreatment EEG was normal. Management of patients, with particular reference to the EEG abnormalities, is discussed.

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