Treatment of Trichinosis with Mebendazole

Michael L. LevinDivision of Infectious Diseases, Sinai Hospital of Baltimore, Inc., Belvedere and Greenspring Avenues, Baltimore, Maryland 21215

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Prolonged oral high-dose mebendazole therapy provided an effective anthelmintic regimen for trichinosis unresponsive to steroid therapy in one patient. Side effects were limited to a Herxheimer-like reaction. Serum mebendazole levels documented gastrointestinal absorption. Repeat muscle biopsies and fluorescein angiography substantiated objective improvement.