Characterization of Eight New Phlebotomus Fever Serogroup Arboviruses (Bunyaviridae: Phlebovirus) from the Amazon Region of Brazil

Amelia P. A. Travassos Da Rosa Instituto Evandro Chagas, Fundaçāo Servicos de Saúde Pública, Ministerio da Saúde, CP 621, 66.000 Belém, Pará, Brazil

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Robert B. Tesh Yale Arbovirus Research Unit, Department of Epidemiology and Public Health, Yale University School of Medicine, P. O. Box 3333, New Haven, Connecticut 06510

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Francisco P. Pinheiro Instituto Evandro Chagas, Fundaçāo Servicos de Saúde Pública, Ministerio da Saúde, CP 621, 66.000 Belém, Pará, Brazil

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Jorge F. S. Travassos Da Rosa Instituto Evandro Chagas, Fundaçāo Servicos de Saúde Pública, Ministerio da Saúde, CP 621, 66.000 Belém, Pará, Brazil

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Norman E. Peterson U.S. Army Medical Research Unit, Belém, Pará, Brazil

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Eight new members of the phlebotomus fever arbovirus serogroup (family Bunyaviridae; genus Phlebovirus) from the Amazon region of Brazil are described. One serotype was recovered from a febrile patient, three from small wild animals and four from sand flies. A small serum survey carried out with the human isolate, Alenquer virus, suggests that it rarely infects man. Complement-fixation and plaque reduction neutralization tests were done, comparing the eight new viruses with other members of the phlebotomus fever serogroup. A close antigenic relationship was demonstrated between one of the new agents (Belterra) and Rift Valley fever virus. This finding is of considerable interest and deserves further investigation. Addition of these eight new viruses to the genus Phlebovirus brings to 14 the number of serotypes known to occur in the Amazon region and to 36 the total number reported worldwide. More detailed clinical and epidemiological studies should be conducted in Amazonia in order to define the public health impact caused by phleboviruses.

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