Immunization of Mice with Ultraviolet-Irradiated Schistosoma Mansoni Cercariae: A Re-Evaluation

David A. Dean Naval Medical Research Institute, Bethesda, Maryland 20814

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K. Darwin Murrell Animal Parasitology Institute, U.S. Department of Agriculture, Beltsville, Maryland 20705

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Xu Shoutai The Shanghai Laboratory of Animal Schistosomiasis, The Chinese Academy of Agricultural Science, Shanghai, People's Republic of China

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Beverly L. Mangold Naval Medical Research Institute, Bethesda, Maryland 20814

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Mice immunized by percutaneous exposure to ultraviolet-irradiated Schistosoma mansoni cercariae developed levels of resistance to subsequent S. mansoni infection comparable to those induced by gamma-irradiated cercariae (50–70% reduction in adult worm burden). Cercariae treated with ultraviolet doses ranging from one to three times the minimum dose required to prevent long-term survival induced the highest levels of resistance.

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