Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
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0002-9637
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In Vitro Cultivation of the Exoerythrocytic Stage of Plasmodium Berghei in a Hepatoma Cell Line

Michael R. HollingdaleBiomedical Research Institute, 12111 Parklawn Drive, Rockville, Maryland 20852

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Pamela LelandBiomedical Research Institute, 12111 Parklawn Drive, Rockville, Maryland 20852

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Alan L. SchwartzDivision of Pediatric Hematology-Oncology, Children's Hospital Medical Center, Sidney Farber Cancer Institute, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115

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DOI:
https://doi.org/10.4269/ajtmh.1983.32.682
Volume/Issue:
Volume 32: Issue 4
Page(s):
682–684
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When inoculated with sporozoites of Plasmodium berghei, a line of hepatoma cells (HepG2-A16) derived from human liver supports the complete asexual developmental cycle of the exoerythrocytic stage. Parasites were shown to resemble parasites in vivo in hepatocytes. Subinoculation of merozoites into mice induced a red blood cell infection.
Copyright:
Copyright © 1983 by The American Society of Tropical Medicine and Hygiene 1983
Accepted:
19 Nov 1982
|
Published Online:
Jul 1983
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