Falciparum Malaria: Accidental Transmission to Man by Mosquitoes after Infection with Culture-Derived Gametocytes

Jackie L. WilliamsDepartment of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Bruce T. InnisDepartment of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Thomas R. BurkotDepartment of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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David E. HayesDepartment of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Imogene SchneiderDepartment of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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A case of falciparum malaria accidentally acquired in the laboratory is reported here. The infection apparently resulted from sporozoite transmission by mosquitoes which were infected with Plasmodium falciparum gametocytes produced in vitro.

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