Falciparum Malaria: Accidental Transmission to Man by Mosquitoes after Infection with Culture-Derived Gametocytes

Jackie L. Williams Department of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Bruce T. Innis Department of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Thomas R. Burkot Department of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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David E. Hayes Department of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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Imogene Schneider Department of Immunology and Department of Entomology, Walter Reed Army Institute of Research, and Division of Infectious Diseases, Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20012

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A case of falciparum malaria accidentally acquired in the laboratory is reported here. The infection apparently resulted from sporozoite transmission by mosquitoes which were infected with Plasmodium falciparum gametocytes produced in vitro.

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