A Simple Field Kit for the Determination of Drug Susceptibility in Plasmodium Falciparum

Phuc Nguyen-DinhMalaria Branch, Parasitic Diseases Division, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Section de Recherches, Service National des Endemies Majeures, Ministère de la Santé, Atlanta, Georgia 30333, Republic of Haiti

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Roc MagloireMalaria Branch, Parasitic Diseases Division, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Section de Recherches, Service National des Endemies Majeures, Ministère de la Santé, Atlanta, Georgia 30333, Republic of Haiti

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William ChinMalaria Branch, Parasitic Diseases Division, Center for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human Services, Section de Recherches, Service National des Endemies Majeures, Ministère de la Santé, Atlanta, Georgia 30333, Republic of Haiti

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A field kit has been developed which greatly simplifies the performance of the 48-hour in vitro test for drug resistance in Plasmodium falciparum. The kit uses an easily reconstituted lyophilized culture medium, and requires only a fingerprick blood sample. In parallel tests with 13 isolates of P. falciparum in Haiti, the new technique had a success rate equal to that of the previously described method, with comparable results in terms of parasite susceptibility in vitro to chloroquine and pyrimethamine.

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