Junin Virus Infection of Callithrix Jacchus: Pathologic Features

Pedro H. GonzálezDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina

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Rubén P. LaguensDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina

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Marcelo J. FrigerioDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina

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Miguel A. CalelloDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina

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Mercedes C. WeissenbacherDepartamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina

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Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.

Author Notes

Members of Research Career from CONICET, Argentina.

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