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Junin Virus Infection of Callithrix Jacchus: Pathologic Features
Pedro H. González
Pedro H. González
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina
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Rubén P. Laguens
Rubén P. Laguens
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina
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Marcelo J. Frigerio
Marcelo J. Frigerio
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina
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Miguel A. Calello
Miguel A. Calello
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina
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Mercedes C. Weissenbacher
Mercedes C. Weissenbacher
Departamento de Patología, Facultad de Ciencias Médicas, Universidad Nacional de la Plata, and Cátedra de Microbiología, Parasitología e Immunología, Facultad de Medicina, Universidad Nacional de Buenos Aires, Argentina
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Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.
Author Notes
Members of Research Career from CONICET, Argentina.
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