| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1010 | 766 | 13 |
| Full Text Views | 6 | 3 | 0 |
| PDF Downloads | 2 | 0 | 0 |
Tegumental Expression in Larval and Adult Stages of a Major Schistosome Structural Glycoprotein
William S. Aronstein
William S. Aronstein
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by William S. Aronstein in
Current site
Google Scholar
PubMed
Search for other papers by William S. Aronstein in
Current site
Google Scholar
PubMed
Amy P. Norden
Amy P. Norden
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by Amy P. Norden in
Current site
Google Scholar
PubMed
Search for other papers by Amy P. Norden in
Current site
Google Scholar
PubMed
Mette Strand
Mette Strand
Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205
Search for other papers by Mette Strand in
Current site
Google Scholar
PubMed
Search for other papers by Mette Strand in
Current site
Google Scholar
PubMed
A monoclonal antibody has been used to identify and characterize an antigenic tegumental surface membrane glycoprotein of Schistosoma mansoni. Direct binding of 125I-labeled monoclonal antibody showed that this glycoprotein was present in eggs, cercariae, and worms of both sexes. The glycoprotein had an apparent molecular weight of 180,000. Indirect and direct immunofluorescent microscopy showed that this antigen was located on the interlinked tegumental folds of both larval and adult parasites. These findings are discussed in relation to parasite development and the mechanism by which schistosomes evade the host's immune defenses.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1010 | 766 | 13 |
| Full Text Views | 6 | 3 | 0 |
| PDF Downloads | 2 | 0 | 0 |