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A Microassay for Detecting Merozoite Inhibition Suitable for Routine Laboratory use
Neil Cowen
Neil Cowen
Department of Pathology, Faculty of Medicine, The University of Newcastle and Hunter Immunology Unit, Royal Newcastle Hospital, Papua New Guinea Institute of Medical Research, Newcastle, NSW, Australia
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Robert Clancy
Robert Clancy
Department of Pathology, Faculty of Medicine, The University of Newcastle and Hunter Immunology Unit, Royal Newcastle Hospital, Papua New Guinea Institute of Medical Research, Newcastle, NSW, Australia
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Allan Cripps
Allan Cripps
Department of Pathology, Faculty of Medicine, The University of Newcastle and Hunter Immunology Unit, Royal Newcastle Hospital, Papua New Guinea Institute of Medical Research, Newcastle, NSW, Australia
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Michael Alpers
Michael Alpers
Department of Pathology, Faculty of Medicine, The University of Newcastle and Hunter Immunology Unit, Royal Newcastle Hospital, Papua New Guinea Institute of Medical Research, Newcastle, NSW, Australia
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A micro semiautomative assay of merozoite inhibition antibody has been developed, based on incorporation of radiolabeled isoleucine into parasite protein. The assay has been validated using 44 sera from healthy blood donors in Madang. Inhibition of uptake of label occurred in 43.2% of tests, while an enhancement of uptake was demonstrated in 4.7%. This assay has ‘potential’ for both seroepidemiological studies, and for providing a mechanism of biotyping wild isolates.
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| Past two years | Past Year | Past 30 Days | |
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