Quinine Loading Dose in Cerebral Malaria

Nicholas J. White Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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Sornchai Looareesuwan Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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David A. Warrell Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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Mary J. Warrell Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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Pornthep Chanthavanich Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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Danai Bunnag Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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Tranakchit Harinasuta Faculty of Tropical Medicine, Mahidol University, Tropical Medicine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Department of Tropical Medicine, Liverpool School of Tropical Medicine, 42016 Rajvithi Road, Bangkok 4, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1983.32.1
Volume/Issue:
Volume 32: Issue 1
Page(s):
1–5
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In cerebral malaria, the use of currently recommended doses of intravenous quinine may result in subtherapeutic plasma concentrations during the critical first 24 hours of treatment. A loading dose of quinine (20 mg/kg quinine dihydrochloride, equivalent to 16.7 mg/kg base, infused over 4 hours) proved a rapid and safe method of achieving plasma concentrations above the high minimum inhibitory concentrations for Plasmodium falciparum prevalent in Eastern Thailand.

Author Notes

Copyright:
Copyright © 1983 The American Society of Tropical Medicine and Hygiene 1983
Accepted:
16 Jun 1982
|
Published Online:
Jan 1983
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Expert Committee on Hepatitis

First Report. World Health Organization Technical Report Series No. 62 (Available also in French). 26 pp. Geneva, W.H.O., Palais des Nations. March, 1953. Price 1/6, $0.20, Fr. fr. 65.-; Sw. fr. 0.80

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