Evaluation of the Antimalarial Activity of the Phenanthrenemethanol Halofantrine (WR 171,669)

Thomas M. CosgriffWalter Reed Army Institute of Research, Washington, D.C. 20012

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Ellen F. BoudreauWalter Reed Army Institute of Research, Washington, D.C. 20012

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Charles L. PamplinWalter Reed Army Institute of Research, Washington, D.C. 20012

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E. Brian DoberstynWalter Reed Army Institute of Research, Washington, D.C. 20012

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Robert E. DesjardinsWalter Reed Army Institute of Research, Washington, D.C. 20012

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Craig J. CanfieldWalter Reed Army Institute of Research, Washington, D.C. 20012

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Abstract. Halofantrine (WR 171,669) was administered to 27 nonimmune subjects infected with the multi-drug resistant Vietnam Smith strain of Plasmodium falciparum. It was also administered to three other subjects, one infected with the Cambodian Buchanan strain of P. falciparum, and two with blood-induced infection with the Chesson strain of P. vivax. It cured infections with all three parasites. Against the highly chloroquine-resistant Smith strain, it was curative in single day treatment regimens. The drug was well tolerated and produced rapid clearance of parasitemia in every case.

Author Notes

Present address: World Health Organization, The Malaria Division, Ministry of Public Health, Devavesm Palace, Bangkok 2, Thailand.

Present address: Head, Anti-Infectives Section, Medical Department, Burroughs Wellcome Co., 3030 Cornwallis Road, Research Triangle Park, North Carolina 27709.

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