Pathology of Lassa Virus Infection in the Rhesus Monkey

Robert T. Callis United States Army Medical Research Institute of Infectious Diseases Fort Detrick, Frederick, Maryland 21701

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Peter B. Jahrling United States Army Medical Research Institute of Infectious Diseases Fort Detrick, Frederick, Maryland 21701

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Alexander DePaoli United States Army Medical Research Institute of Infectious Diseases Fort Detrick, Frederick, Maryland 21701

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The clinical signs and gross and microscopic lesions of Lassa virus infection in the rhesus monkey are described. Of 17 monkeys infected with Lassa virus, nine died or were killed when moribund. The clinical signs were lethargy, aphagia, constipation, fever, conjunctivitis, and skin rash. Pulmonary congestion, pleural effusion, pericardial edema, hydropericardium, and a few visceral hemorrhages were present grossly. Major microscopic lesions were necrotizing hepatitis and interstitial pneumonia. Other microscopic changes were present in the heart, small intestine, spleen, lymph nodes, kidney, urinary bladder, adrenal glands, and central nervous system; however, most of these lesions were mild. In fact, death could not always be attributed to the morphologic changes; therefore, function alterations must be examined.

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