Dengue Virus-Specific and Flavivirus Group Determinants Identified with Monoclonal Antibodies by Indirect Immunofluorescence

E. A. HenchalDepartment of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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M. K. GentryDepartment of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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J. M. McCownDepartment of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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W. E. BrandtDepartment of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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Monoclonal antibodies produced against the four dengue virus serotypes identified four categories of reactions by immunofluorescence: flavivirus group reactive, dengue complex specific, dengue subcomplex specific (DEN-1, DEN-3), and dengue serotype specific. This is the first time that monospecific antibodies have been available for all of these unique antigenic determinants. Hybridoma cell lines producing dengue type-specific antibodies have been deposited in the Hybridoma Cell Bank of the American Type Culture Collection (Rockville, MD) for general distribution.

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