Dengue Virus-Specific and Flavivirus Group Determinants Identified with Monoclonal Antibodies by Indirect Immunofluorescence

E. A. Henchal Department of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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M. K. Gentry Department of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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J. M. McCown Department of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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W. E. Brandt Department of Virus Diseases and Biochemistry, Walter Reed Army Institute of Research, Washington, D.C. 20012

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DOI:
https://doi.org/10.4269/ajtmh.1982.31.830
Volume/Issue:
Volume 31: Issue 4
Page(s):
830–836
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Monoclonal antibodies produced against the four dengue virus serotypes identified four categories of reactions by immunofluorescence: flavivirus group reactive, dengue complex specific, dengue subcomplex specific (DEN-1, DEN-3), and dengue serotype specific. This is the first time that monospecific antibodies have been available for all of these unique antigenic determinants. Hybridoma cell lines producing dengue type-specific antibodies have been deposited in the Hybridoma Cell Bank of the American Type Culture Collection (Rockville, MD) for general distribution.

Author Notes

Accepted:
15 Jan 1982
|
Published Online:
Jul 1982
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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