We appreciate the interest in our study shown by Dr. Ringelhann. We were unaware of the article referenced in the American Journal of Human Genetics. If the authors had included the source of their material, Ghana, in their title, it might have come to our attention. Their cross-sectional study, done in 1964, represents a considerable achievement and the results were interesting and worthwhile.
Our study was focussed quite differently, however. In 1978 we undertook a longitudinal study of a few infants, in the hope of determining their clinical and serological responses to primary infection in infancy, and presented the results as the substance of the manuscript. We noted, somewhat parenthetically, our surprise that so few episodes of malaria seroconversion occurred, given the frequency with which this disease is diagnosed clinically. However, we recognized that these 31 infants could not constitute “a meaningful selection” of the population of Accra, and stated that we were collecting data to examine the question of incidence.